Methionine aminopeptidases with a universal specificity have been revealed from the sequences of the amino‐terminal region of mutant forms of yeast iso‐1‐cytochrome c and from a systematic examination of the literature for amino‐terminal sequences formed at initiation sites. The aminopeptidase removes amino‐terminal residues of methionine when they precede certain amino acids, with a specificity that appears to be determined mainly by the residue adjacent to the methionine residue at the amino terminus. The result with the mutationally altered iso‐1‐cytochromes c and (...) the results from published sequences of other proteins from a wide range of prokaryotes and eukaryotes suggest that the aminopeptidase usually cleaves amino‐terminal methionine when it precedes residues of alanine, cysteine, glycine, proline, serine, threonine and valine but not when it precedes residues of arginine, asparagine, aspartic acid, glutamine, glutamic acid, isoleucine, leucine, lysine or methionine. We suggest that the specificity is almost always determined simply by the size of the side chain of the penultimate residue; methionine is usually cleaved from residues with a side chain having a radius of gyration of 1·29 Å or less, but is not cleaved from residues with larger side chains. (shrink)

This is a comprehensive reference source on 18th-century authors writing in the English language about philosophical ideas and issues. It features authors taken from 1689 through to the mid-19th century, the period beginning with John Locke and ending with Dugald Stewart. The word philosophical is used in a wide, 18th-century sense. Therefore, the Dictionary includes epistemology, ethics, aesthetics, education, politics, rhetoric, science, medicine, biology, geology, chemistry and theology.

This article is about the history of logic in Australia. Douglas Gasking (1911?1994) undertook to translate the logical terminology of John Anderson (1893?1962) into that of Ludwig Wittgenstein's (1921) Tractatus. At the time Gilbert Ryle (1900?1976), and more recently David Armstrong, recommended the result to students; but it is reasonable to have misgivings about Gasking as a guide to either Anderson or Wittgenstein. The historical interest of the debate Gasking initiated is that it yielded surprisingly little information about Anderson's (...) traditional (syllogistic or Aristotelian) logic and its relation to classical (first-order predicate or Russellian) logic, the ostensible topic; but the materials now exist to interpret Anderson's logic in classical logic, possibly as an algebra of classes. This would be of little interest to contemporary logicians, but it might shed some light on Anderson's philosophy. (shrink)

DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers can freely discuss current and emerging deep brain stimulation technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in (...) its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury. (shrink)

Originally published in 1830, this book can be called the first modern work in the philosophy of science, covering an extraordinary range of philosophical, methodological, and scientific subjects. "Herschel's book . . . brilliantly analyzes both the history and nature of science."—Keith Stewart Thomson, American Scientist.

The representational theory of phenomenal experience is often stated in terms of a supervenience thesis: Byrne recently characterises it as the thesis that “there can be no difference in phenomenal character without a difference in content”, while according to Tye, “[a]t a minimum, the thesis is one of supervenience: necessarily, experiences that are alike in their representational contents are alike in their phenomenal character.” Consequently, much of the debate over whether representationalism is true centres on purported counter-examples – that is (...) to say, purported failures of supervenience. The refutation of putative counter-examples has been, it seems to me, by and large successful. But there is a certain class of these for which the representationalist response has been something less than completely convincing. These are the cross-modality cases. I will explain what I mean, and then argue that the response in question is not only unconvincing but actually undermines the representationalist position. (shrink)

Our understanding of how evolution acts on biological networks remains patchy, as is our knowledge of how that action is best identified, modelled and understood. Starting with network structure and the evolution of protein–protein interaction networks, we briefly survey the ways in which network evolution is being addressed in the fields of systems biology, development and ecology. The approaches highlighted demonstrate a movement away from a focus on network topology towards a more integrated view, placing biological properties centre‐stage. We argue (...) that there remains great potential in a closer synergy between evolutionary biology and biological network analysis, although that may require the development of novel approaches and even different analogies for biological networks themselves. (shrink)

This paper examines one of the historical antecedents of Big Data, the social physics movement. Its origins are in the scientific revolution of the 17th century in Western Europe. But it is not named as such until the middle of the 19th century, and not formally institutionalized until another hundred years later when it is associated with work by George Zipf and John Stewart. Social physics is marked by the belief that large-scale statistical measurement of social variables reveals (...) underlying relational patterns that can be explained by theories and laws found in natural science, and physics in particular. This larger epistemological position is known as monism, the idea that there is only one set of principles that applies to the explanation of both natural and social worlds. Social physics entered geography through the work of the mid-20th-century geographer William Warntz, who developed his own spatial version called “macrogeography.” It involved the computation of large data sets, made ever easier with the contemporaneous development of the computer, joined with the gravitational potential model. Our argument is that Warntz's concerns with numeracy, large data sets, machine-based computing power, relatively simple mathematical formulas drawn from natural science, and an isomorphism between natural and social worlds became grounds on which Big Data later staked its claim to knowledge; it is a past that has not yet passed. (shrink)

This article commemorates Jean Baudrillard’s career with an account of the consistency of his interventionist logic, the subtlety of his styles of argument and the prescience of his observations. It provides an account of Baudrillard’s sustained engagement with the intensification of simulation that has increasingly codified trends in communications, technology politics, the social, the psychological and economics in the name of functionality. The consistency of Baudrillard’s arguments belies the many superficial judgements made about them, which were anyway often knowingly encouraged (...) by Baudrillard’s rhetorical strategies. (shrink)

This volume explores whether the concept of the common good might be retrieved and become central in contemporary religious social thought. Contributors include: Charles C. West, John J. Collins, Ralph McInerny; J. Philip Wogaman, Charles E. Curran, Richard John Neuhaus, Dennis P. McCann, Ernest Bartell, Michael Novak, Charles K. Wilber, John W. Cooper, Gar Alperovitz, Richard T. DeGeorge, Gerald Cavanagh, William J. Cunningham, Peter Mann, Bette Jean Bullert and David Vogel. Co-published with the Notre Dame Center for (...) Ethics and Religious Values in Business. (shrink)

In this article we outline the ways in which questions of language have both revealed problems with conceptions of knowledge and suggested constructive ways of addressing those problems. Having examined the limitations of instrumental notions of language, we outline some alternatives, especially those developed from the middle of the 19th and throughout the 20th century. We locate forceful and influential philosophical interventions in the writings of Nietzsche and Heidegger and foundational revisions in the linguistics of Ferdinand de Saussure and his (...) structuralist inheritors. We also chart the parallel path of literary theory from Mallarmé through Blanchot and poststructuralism to deconstruction. We conclude, after making some observations about the politicization of language in the works of feminist and postcolonial theorists, with some remarks about how the question of language helps to problematize global knowledge. (shrink)

The virulence of a virus is determined by its ability to adversely affect the host cell, host organism or population of host organisms. Influenza A viruses have been responsible for four pandemics of severe human respiratory disease this century. Avian species harbour a large reservoir of influenza virus strains, which can contribute genes to potential new pandemic human strains. The fundamental importance of understanding the role of each of these genes in determining virulence in birds and humans was dramatically emphasised (...) by the recent direct transmission of avian influenza A viruses to humans, causing fatal infection but not community spread. An understanding of the factors involved in transmission between avian and mammalian species should assist in the development of better surveillance strategies for early recognition of influenza A virus strains having human pandemic potential, and possibly in the design of anti‐viral strategies. BioEssays 25:657–671, 2003. © 2003 Wiley Periodicals, Inc. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Hume Studies Volume XXI, Number 2, November 1995, pp. 151-164 On Hume's Conservatism DONALD W. LIVINGSTON In Opinion and Reform in Hume's Political Philosophy,1 John Stewart seeks to establish two theses. The first is that Hume's philosophical skepticism does not entail political conservatism as many commentators have argued, and the second is that central to all of Hume's writings, but especially to the History and the Essays, (...) is a program of major reforms. These include an ethic of individualism and cosmopolitanism, protection of private property, representative government under the rule of law, free trade, anti-imperialism, and moderate secularization. Stewart is right, I think, that these reforms are central to Hume's philosophic project, and he explores them with historical depth and subtlety. What is not so convincing, however, at least in the form presented, is the thesis that Hume is a liberal and not a conservative. And it is this thesis that I wish to explore. The first thing to appreciate is the sense in which Hume is neither a liberal nor a conservative. These are early nineteenth century terms framed to characterize a political and intellectual response to the French Revolution and to the Industrial Revolution. Liberalism and conservatism were not and could not have been a part of Hume's own self-understanding. That understanding is revealed clearly enough in Hume's remark that he was a whig in respect to "things" and a tory in respect to "persons" (HL II237). That is, he admired the moral character of Charles I and leading royalists more than the characters of Cromwell and the Puritan fanatics. But he was happy about the unintended consequences of the Puritan rebellion which led to the constitution of liberty Donald W. Livingston is at the Philosophy Department, Emory University, 214 Bowden Hall, Atlanta GA 30322 USA. 152 Donald W. Livingston of 1689 (the whig order of "things," namely liberty and the rule of law). But though Hume could not have thought of himself as a liberal or a conservative, it is possible to find intimated in his philosophy a pattern of thought significantly similar to a later structure of thought which may properly be called liberal or conservative as the case may be. Such retrospective judgments are legitimate as long as there is sufficient evidence to support the appropriate historical claim about what Hume did and thought he had done and an adequate philosophical theory of what liberalism and conservatism are. But if Hume is to be recruited as part of a liberal or conservative political tradition, we must be clear about what is meant by the terms 'liberal' or 'conservative '. And this is no easy matter; for these terms have not only changed their meanings over time, they are highly contested terms, being in their very nature partisan expressions the explication of which cannot entirely escape a political commitment. What I find unsatisfactory about Stewart's thesis that Hume should not be thought of as part of the conservative political tradition is not so much what he says about the critical and reforming character of Hume's thought (in that he is essentially correct) as that he does not offer a philosophical theory of conservatism or liberalism. The result is that much of the liberalism he finds in Hume would be embraced by self-professed conservatives, and some of what he characterizes as conservatism would be denied. One must gather Stewart's meaning for these terms from various contexts. In some places a conservative is thought of as a philosophical skeptic who has nothing to cling to but the raft of custom and is, consequently, incapable of making judgments of truth. Or, a conservative may be one who can indeed make judgments but is uncritical and perhaps even bigoted in doing so. Or finally, a conservative may be one whose character is informed by an ungenerous disposition to defend the status quo regardless of the oppression of others.2 Stewart argues that Hume is not a conservative in these senses but is a critical political theorist whose philosophical skepticism not only did not prohibit, but positively legitimated the formulation of truths about political things. In his... (shrink)

In this brief and readable survey of the Reformation in Scotland, Professor Renwick succeeds in supplying both a sketch of the pre-Reformation church in Scotland, and an account of the entanglements of blood, religion and politics involving the Scottish throne. Frankly written from the Protestant point of view, the author demonstrates restraint in his treatment of the role of Mary Stewart, and gives an interesting narrative of John Knox's part in bringing about the reformation of the church.--S. M. (...) W. (shrink)

In this study John W. Elrod demonstrates that Kierkegaard's pseudonymous writings have an ontological foundation that unites the disparate elements of these books. The descriptions of the different stages of human development are not fully understandable, the author argues, without an awareness of the role played by this ontology in Kierkegaard's analysis of human existence. Kierkegaard contends that the self is a synthesis of finitude and infinitude, body and soul, reality and ideality, necessity and possibility, and time and eternity. (...) Each of these syntheses reveals a particular and unique aspect of individual being not disclosed in the others. Part One shows that ontology is central to the discussion of the self in the pseudonyms. The author notes that spirit, as a synthesis of the expressions of the self, develops as consciousness and freedom. In Part Two he indicates the relationship between notions of being and existence. He notes that existence, in Kierkegaard's thought, grows out of the life of the spirit; the different stages of existence are concrete modes that develop in the spirit's striving to unify the self as a synthesis. These existential expressions of spirit are dialectically related, in that each step requires the preceding stages of spiritual development. Originally published in 1975. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

Using his intimate knowledge of John Locke's writings, John W. Yolton shows that Locke comprehends 'human understanding' as a subset of a larger understanding ...

Algorithmic fairness is a new interdisciplinary field of study focused on how to measure whether a process, or algorithm, may unintentionally produce unfair outcomes, as well as whether or how the potential unfairness of such processes can be mitigated. Statistical discrimination describes a set of informational issues that can induce rational (i.e., Bayesian) decision-making to lead to unfair outcomes even in the absence of discriminatory intent. In this article, we provide overviews of these two related literatures and draw connections between (...) them. The comparison illustrates both the conflict between rationality and fairness and the importance of endogeneity (e.g., “rational expectations” and “self-fulfilling prophecies”) in defining and pursuing fairness. Taken in concert, we argue that the two traditions suggest a value for considering new fairness notions that explicitly account for how the individual characteristics an algorithm intends to measure may change in response to the algorithm. (shrink)

In 1984, John W. Yolton published Perceptual Acquaintance from Descartes to Reid. His most recent book builds on that seminal work and greatly extends its relevance to issues in current philosophical debate. Perception and Reality examines the theories of perception implicit in the work of seventeenth- and eighteenth-century philosophers which centered on the question: How is knowledge of the body possible? That question raises issues of mind-body relation, the way that mentality links with physicality, and the nature of the (...) known world. In contrast to commonsense realism, which suggests that the world is as it appears to be, a more complex theory developed throughout this period. Yolton traces its evolution from Descartes to Kant, via Arnauld, Malebranche, Locke, Berkeley, and Hume. Yolton explains that the new theory postulated two interactive relations between perceivers and the physical world, one physical and causal, the other cognitive. An understanding of this double relation is important for an accurate construction of the history of philosophy. It is also important for contemporary thought because it suggests a way to account for representation (cognitivity) and realism at the same time. (shrink)

I want to discuss a doctrine and a concept in theory of knowledge which has various manifestations from at least the seventeenth to the early twentieth century. The concept is that of direct or immediate cognition, the doctrine says that only what is like mind can be directly or immediately present to mind. This doctrine raises the question of how we can know things other than ourselves and our experiences: the concept of direct presence most usually had the consequence of (...) making our knowledge of the world indirect, uncertain, or impossible. The directly present must in some way inform us about the indirectly present. (shrink)

The Essay Concerning Human Understanding is John Locke's most important work, and through this selective commentary, first published in 1970, Professor Yolton concentrates our attention on the more interesting and controversial of the doctrines in it. His method of interpretation is to ask very specific questions of the text in order to test the propriety of the philosophical labels traditionally applied to Locke, an approach which he believes yields surprising results. He looks afresh at the various discussions of essence, (...) perception, scientific method, ethics and meaning, and argues that throughout his epistemology Locke is more concerned with problems of description and analysis than with those of justification. This historical perspective is extended by the discussion of issues in the Essay, which retain an independent and philosophical interest. (shrink)

When the Senate released its so-called "Torture Report" in December 2014 the world would learn that, for years, the CIA had used unimaginably brutal methods to interrogate its prisoners - often without yielding any useful or truthful information. The agency had long and adamantly defended its use of torture, staunchly arguing that it was not only just but necessary for the country's safety. And even amid the revelations of the report, questions abound about whether torture can be considered a justifiable (...) tool of national security. Is interrogational torture an effective method of extracting information? How good does the information extracted need to be for the torture to be considered successful? How often or how vigorously must torture be used to achieve valuable information? It may be the case that interrogational torture can never be justified under any circumstances, but, according to John Schiemann, if it is to be justified at all, it must be effective. According to more than one national poll, most Americans do believe that torture can work, and that it can be justified under certain circumstances. But if the information that torturers extract is bad, then the method amounts to nothing more than pure sadism. So, how can we solve the dilemma over whether to torture or not to torture? In this book, John Schiemann takes a truly unique approach to the question of torture: game theory. Thinking of torture as a "game" played between an interrogator and a detainee, the book walks the reader through the logic of interrogational torture, comparing the outcomes to the claims made by torture proponents. The book draws on a wide variety of sources ranging from records of the Inquisition to secret CIA memos to trace this logic, illustrating each outcome of the model with a narrative from the real world of interrogational torture. Does Torture Work? is an absorbing and provocative take on one of the most discussed human rights and security dilemmas of our time. (shrink)

Reform of the federal income tax system has become a perennial item on the domestic policy agenda of the United States, although there is considerable uncertainty over specifics. Indeed the recent report of the President's Advisory Panel on Federal Tax Reform recommended not one but two divergent policy directions. In Fundamental Tax Reform, top experts in tax policy discuss a wide range of issues raised by the prospect of significant tax reform, identifying the most critical questions and considering whether the (...) answers are known, unknown--or unknowable. The debates over tax reform usually concern the advantages and disadvantages of income-based taxation as opposed to any of the several alternative forms of consumption-based taxation. The book opens with chapters that discuss the strengths, weaknesses, and political feasibility of these options. Other chapters consider the effect of tax reform on businesses, especially their investment behavior, and include a discussion of possible problems in any transition to a consumption-based tax; international taxation issues arising in an era of globalization; and individual behavioral response to tax reform, including a view of the topic from the perspective of the relatively new field of behavioral economics. ContributorsRosanne Altshuler, Alan J. Auerbach, John W. Diamond, Harry Grubert, Arnold C. Harberger, Kevin A. Hassett, Thomas J. Kniesner, Laurence J. Kotlikoff, Edward J. McCaffery, Kathryn Newmark, David Rapson, Daniel Shaviro, Joel Slemrod, James P. Ziliak, George R. ZodrowDiscussants James Alm, Henry J. Aaron, Charles L. Ballard, Leonard E. Burman, Robert S. Chirinko, Robert D. Dietz, Malcolm Gillis, Roger H. Gordon, Jane G. Gravelle, Timothy S. Gunning, James M. Poterba, Thomas S. Neubig, Alan Viard, George Yin John W. Diamond is Edward and Hermena Kelly Fellow in Tax Policy and Adjunct Professor of Economics at the Baker Institute for Public Policy, Rice University. George R. Zodrow is Professor of Economics and Rice Scholar at the Baker Institute and International Research Fellow at the Centre for Business Taxation, Oxford University. (shrink)

Leibniz has been widely praised for maintaining against the Newtonians of his day the view that space and time are relative. At the same time, he has been roundly criticized for allowing that we can distinguish absolute from merely relative motion. This distribution of applause and criticism, I will argue, is in a measure unjustified. For on the one hand, those arguments, found in his correspondence with Clarke, by which Leibniz seeks to reject the view that space and time are (...) “something absolute” are for the most part unsatisfactory, and on the other hand, Leibniz was not so naive as his critics have supposed in allowing absolute motions. Sections I ‐ V of this essay will be concerned with the former issue; Leibniz's views on motion will be taken up in Section VI. The chief interest in all of this for present‐day philosophers may lie, not so much in the historical issues concerning Leibniz and the Newtonians, but in a meta‐philosophical question which inevitably arises from the historical issues, namely, the question whether developments in science can undermine the soundness of philosophical arguments which appeal to ordinary usage. (shrink)

“How to Read Wittgenstein” is a discussion of some misinterpretations that arise when Ludwig Wittgenstein's later works are read, not in their historical context, but as though they were written for a generation of philosophers influenced by G.E. Moore and ordinary language philosophy. The criticisms are directed primarily at Oswald Hanfling's “Critical Notice” in Philosophical Investigations 19:2 (April, 1996).

The A to Z of Hegelian Philosophy covers all aspects of Hegel's thought. It discusses his students and colleagues, as well as key figures who either adopted his thought or attempted to explicate it for later generations. This is done through a chronology, an introductory essay, a glossary of German terms, a bibliography, and over 500 cross-referenced dictionary entries.